Making Discoveries that Make a Difference

Research Services

  • Molecular Biological Techniques Accuri C6 Flow Cytometer four-color detection
  • Laser Capture Microdissection—Dissection of individual pathogen-infected cells for performing proteomic, genomic, and transcriptomic analysis of tissue section
  • Imaging—Nikon TE-2000 confocal microscope equipped with a live cell imaging system
  • Universal Plate Reader—Luminescent, fluorescent, and absorbance-based 96-well assays
  • Proteomics
  • Real-time PCR

 

Available technological platforms

  • Mass Spectrometry (LC-MS/MS, MALDI-MS, LAESI-MS)
  • Reverse Phase protein MicroArray (RPMA) for phospho-proteomics and phospho-signaling
  • Multiplexed profiling of chemokine and cytokine mediators

Applications

  • Vaccine and therapeutic efficacy testing
    • Sample generation and testing using in vitro and in vivo models (challenge studies)
    • Correlates of protection, immunogenicity, efficacy
    • Mechanism of action (adjuvants)
  • Histology  – Necropsy suite with downdraft table and hoodline for the collection of animal tissue samples and histological preparation of tissue to include a cryostat for creating tissue sections:
  • Nanoparticles – Materials that enhance the discovery and preservation of biomarkers in body fluids for diagnostic, therapeutic, and vaccine targets
  • In-vivo imaging  — IVIS Lumina II (Caliper Life Sciences) is an in-vivo imaging system that uses a novel patented optical imaging technology to facilitate non-invasive longitudinal monitoring of disease progression and cell trafficking patterns in living animals. The IVIS system is a versatile and advanced in-vivo imaging system.
  • Virological Assays – Multiple assays are available for the quantification of viral loads, including standard plaque assays, 96-well plaque assays, absolute q-RT-PCR assays, and focus forming assays.
  • Bacterial Assays  –  Assays available include microbial identification through biochemical assays or 16S rRNA, compound library and combinational library screening, minimal inhibitor concentration (MIC) assays, minimal bactericidal concentration (MRC) assays, time-kill kinetic assays, resistance development/mutant selection and microbial quantitation through q-PCR.
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