Animal Model Capabilities
The BRL is equipped to perform research on multiple species such as mice (including humanized mouse models), rats, hamsters, guinea pigs, rabbits, ferrets, and nonhuman primates. The BRL’s professional animal care personnel can provide routine husbandry, as well as technical support for projects involving surgery or requiring ABSL-3 containment and involving work with the U.S. Department of Agriculture and CDC select agents. Animal care staff members are American Association for Laboratory Animal Science (AALAS)-certified. Personnel are trained in all aspects of biocontainment safety practices and procedures and can perform animal work for infectious disease research ranging from weights and daily observations to infections, blood and tissue collection, and full necropsy.
The entire BRL facility was designed to support research on infectious agents in animal models and thus includes extensive animal research capabilities at both the ABSL-2 and ABSL-3 safety levels.
Specific features include:
- A total facility capacity of 10,500 mice, 900 rats, 280 rabbits/ferrets, or 100 nonhuman primates under ABSL-3 containment
- Four dedicated ABSL-3 animal holding suites with an anteroom, animal holding room, and animal procedure room
- A dedicated sterile surgery suite
- Monitoring of animal physiological functions using implantable telemetry with remote monitoring
- Class II Type A2 biosafety cabinets in all animal holding and procedure rooms