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Dr. van Hoek and research associate Stephanie Barksdale published a paper in January 2017 in Developmental and Comparative Immunology, “Cathelicidin antimicrobial peptide from Alligator mississippiensis has antimicrobial activity against multi-drug resistant Acinetobacter baumannii and Klebsiella pneumoniae.” In this paper, Dr. van Hoek and her team describe a powerful cathelicidin peptide from the American alligator. This antimicrobial peptide and fragments have very strong activity against a number of Gram-negative bacteria, including multi-drug resistant strains. Experiments indicate that these peptides work by punching very small holes in the bacterial membrane; however, these peptides do not do the same to mammalian cells.
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