Drs. Kehn-Hall and Narayanan (Co-PI, GMU) have received a five year DTRA grant
Drs. Kehn-Hall and Narayanan (Co-PI, GMU) have received a five year grant from DTRA entitled “Molecular Pathogenesis of Select Agent Viruses and their Attenuated Vaccine Derivatives”. This project is in collaboration with Dr. Connie Schmaljohn’s laboratory at USAMRIID. The objectives of this grant are (1) to identify significant differences at the host response level to Select Agent viruses versus attenuated vaccine counterparts through comparative analyses of host transcriptome and proteome changes, (2) to produce bioinformatic models of host-pathogen relationships and (3) to validate these models using reverse genetic systems and siRNA approaches.