“Proteolytic cleavage of TRIM14 by the VEEV Nonstructural Protein 2 Cysteine Protease”
Dr. Patricia Legler
U.S. Naval Research Laboratory
Dr. Feng Lin, Virginia Tech
Dr. Lin is available to meet with faculty and students from noon to 4:00pm. If you are interested in meeting him, please contact Dr. You at firstname.lastname@example.org with your preferred meeting time.
Rational Design of Variants of Short Antimicrobial Peptides derived from Snake Cathelicidin
(Dr. Barney Bishop, advisor)
“Design and Synthesis of Mitochondrial Citrate Carrier Protein Inhibitors for Treating Lung Cancer AND Design and Synthesis of Inhibitors of Interleukin-1β Protein-Protein Interactions for the Treatment of Osteoarthritis”
Doctoral Candidate (Dr. Mikell Paige, advisor)
Introduction to the semester’s seminar series, by Dr. Young-Ok You.
“The Sphingosine-1-phosphate pathway: Sphingosine kinase as a drug target”
Dr. Webster Santos (Virginia Tech)
Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with its five G-protein coupled receptors (S1P1–5) to regulate cell growth and survival and has been implicated in a variety of diseases including cancer, fibrosis, inflammation, neurodegenerative diseases, and sickle cell disease. As the key mediators in the synthesis of S1P, sphingosine kinase (SphK) isoforms 1 and 2 have attracted attention as viable targets for pharmaceutical inhibition. In this presentation, I will discuss our efforts in inhibiting SphK through extensive medicinal chemistry campaigns. The activity of inhibitors in mice as well as their therapeutic implications will be discussed.
Please email Dr. You at email@example.com if you’d like to meet the speaker.