“Bivalent Ligand Approach to Understand the role of Putative Mu Opioid Receptor and Chemokine Receptor CCR5 Heterodimers in NeuroAIDS”
Dr. Yan Zhang (VCU)
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Characterization of the Acid-base Properties of Selected Humic Substances and Model Compounds
Determination of the surface density of acidic functional groups and the magnitude of pKa ’s of carboxylic and phenolic functional groups is a first step in characterizing acidity, ion exchange capacity, and charge accumulation properties in humic substances (HS). Potentiometric titration was used to determine the fundamental acidic properties of natural HS and selected model HS to better assess the role structure plays in carboxyl and phenol group dissociation.
The model compounds were simple benzofuran (C8H6O) derivatives, a common structural motif in HS. The pKa and Ka values of the model compounds were evaluated accurately and precisely, thus useful to determine structural variations in dissociation. In order to determine the concentration and conditional pKa’s of the ionizable sites, a nonlinear method for fitting acid-base potentiometric titration data, was applied to the HS titrated for this study. Each HS was assumed as a mixture of monoprotic acids in the model.
|10:00 am||- Gautam Subramanian||(Dr. Hussam)|
|Development of Arduino based pH titration system for identification of common drugs|
|10:20 am||- Sanae Moummi||(Dr. Paige)|
|A Simplified Method of Sonogashira Coupling|
|10:40 am||- Silvia Auffret||(Dr. Paige)|
|Synthesis of unsymmetrical bis-alkynes|
|11:00 am||- Mosufa Zainab||(Dr. Couch)|
|Development of Novel Antibiotics Targeting the MEP Pathway|
|11:20 am||- Benjamin McDowell||(Dr. Schreifels)|
|Electrospray Ionization in Mass Spectrometry for the Analysis of Volatiles|
|11:40 am||- Brittany Rapp||(Dr. Hussam)|
|Dynamics of Gold Nanoparticle Formation with Cyclohexanone as Reducing Agent at Room Temperature|
|12:30 pm||- Lunch||Planetary Hall - Room 312|
|Please be prompt and please sign in for lunch attendance|