Chemistry and Biochemistry Seminar: Webster Santos

September 15, 2017 @ 1:00 pm – 2:15 pm
Innovation Hall 131 and Bull Run Hall 258
Young-Ok You

“The Sphingosine-1-phosphate pathway: Sphingosine kinase as a drug target”

Dr. Webster Santos (Virginia Tech)

Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that interacts with its five G-protein coupled receptors (S1P1–5) to regulate cell growth and survival and has been implicated in a variety of diseases including cancer, fibrosis, inflammation, neurodegenerative diseases, and sickle cell disease. As the key mediators in the synthesis of S1P, sphingosine kinase (SphK) isoforms 1 and 2 have attracted attention as viable targets for pharmaceutical inhibition. In this presentation, I will discuss our efforts in inhibiting SphK through extensive medicinal chemistry campaigns. The activity of inhibitors in mice as well as their therapeutic implications will be discussed.

Please email Dr. You at if you’d like to meet the speaker.