Congratulations to the Award Winners for the 2020 Chemistry and Biochemistry Department Awards. Below is the list of winners.
- General Chemistry Achievement Award
Student: Kaci Jose
- Feinstein Award in General Chemistry
Student: Allison Carroll
- ACS Organic Chemistry Award
Student: Gillian (Megan) Payne
- C.R. Walter Award in Organic Chemistry
Student: Shan Zaidi
- Meites-ACS Undergraduate Award in Analytical Chemistry
Student: Moon-Jung (Melony) Kim
- Holly Chen Biophysical Chemistry Award:
Student: Enkhsaruul Sergelenbaatar
- ACS PChem Award
Student: Ume Tahir
- MS Graduate Student Award
Student: Jinghao Huang
- Ph.D. Graduate Student Award
Student: Andrew J. Evangelista
- ACS Senior Award
Student: Tristan Moon
Congratulations to Dr. Rebecca Jones
Congratulations to Dr. Rebecca Jones on the recent publication that focuses on undergraduate research mentoring by underrepresented faculty members. This represents another positive profile of the diverse research areas of CHEM faculty, areas of expertise that do not reside in all departments at the university, and the promotion of GMU to the greater research and educational communities.
Article: Davis, S. N., Garner, P. W., Jones, R. M., & Mahatmya, D. (2020). The role of perceived support and local culture in undergraduate research mentoring by underrepresented minority faculty members: Findings from a multi-institutional research collaboration. Mentoring & Tutoring: Partnership in Learning, 1–13
CONGRATULATIONS to Dr. Hao Jing and his research students
The work performed by Andrew Evangelist and Mariia Ivanchenko (Ph.D. students) was just accepted for publication in the Journal of Materials Chemistry C (impact factor ~ 7) and selected as the back cover of the journal. Andrew and Mariiaare listed as 1st and 2nd author, respectively.
Two undergraduate students ( Lisa McAnulty and Gillian Megan Payne ) also participated in this project and were included in the author list.
Excerpt from Dr. Jing: “Our research on nanoparticles will be specially promoted and highlighted by Royal Society of Chemistry (RSC)! In this paper, George Mason University and Virginia area code -“703” were both used in the interesting anti-counterfeiting application.
Candidate: Haley S. Ball
Program: Doctor of Philosophy in Biochemistry
Date of Defense: April 3, 2020
Time: 11:00 AM
Title: Development of Novel Antibiotics Targeting the First Committed Enzyme in the Methyl Erythritol Phosphate Pathway: MEP Synthase
Join us via Zoom Meeting:
Meeting ID: 181 841 421
Dr. Robin Couch, Dissertation Chair
Dr. Schroeder Noble
Dr. Barney Bishop
Dr. Cynthia Dowd
Dr. John Schreifels
Abstract: The focus of this dissertation research is to develop novel antibiotics targeting the methylerythritol 4-phosphate (MEP) pathway in the following pathogenic organisms: Acinetobacter baumannii and Klebsiella pneumoniae (nosocomial pathogens), Mycobacterium tuberculosis (the causative agent of tuberculosis), Plasmodium falciparum (the causative agent of malaria), and Yersinia pestis (the causative agent of the plague). Bacteria and apicomplexan protozoans utilize the MEP pathway to synthesize isoprenoids, a class of fundamental biomolecules, with critical cellular functions including electron transport and cell wall biosynthesis. Because mammalian cells use a different biochemical pathway for isoprenoid biosynthesis, the MEP pathway is a viable target for antibiotic development. Inhibition of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase/IspC), the first committed enzyme of the MEP pathway, has been achieved with small phosphonic acid compounds such as fosmidomycin. Fosmidomycin suffers from bioavailability issues; however, it has been validated as an inhibitor of isoprenoid biosynthesis in vitro, and thus provides a promising scaffold for further drug development. The goals of this dissertation research are to determine structure-activity relationships (SARs) of rationally designed inhibitors based on the scaffold of fosmidomycin, elucidate the binding mechanisms of select inhibitors via enzyme assays and protein crystallization, and to assess the effect of select IspC inhibitors on targeted MEP pathway metabolite levels in bacterial cell cultures.
Congratulations to Dr. Rebecca Jones on logging another publication for the academic year. The article, “Recruiting and Enrolling Rural Students: A Model for Increasing Diversity in STEM”, is about the RADSS program, which was created from an NSF S-STEM grant.