COLLOQUIUM OF THE COMPUTATIONAL MATERIALS SCIENCE CENTER – CHRISTOPHER LOCKHART – MOLECULAR DYNAMICS SIMULATIONS OF PEPTIDES RELEVANT TO ALZHEIMER’S DISEASE
COLLOQUIUM OF THE COMPUTATIONAL MATERIALS SCIENCE CENTER
AND THE DEPARTMENT OF COMPUTATIONAL & DATA SCIENCES
(CSI 898-Sec 001)
Molecular dynamics simulations of peptides relevant to Alzheimer’s disease
School of Systems Biology
George Mason University
The progression of Alzheimer’s disease has been linked to the aggregation of Aβ peptides. Current theories suggest that Aβ interactions with cellular membranes results in its neurodegenerative effect, although little is known of the molecular mechanism. To probe this mechanism, we performed replica-exchange molecular dynamics simulations of Aβ peptides binding to a model membrane represented by a lipid bilayer.
In this talk I will describe our investigation of the conformational change of Aβ peptides induced by the bilayer, the Aβ binding mechanism, and the impact of Aβ on bilayer structure. Our results find a correlation between the Aβ cytotoxicity and the aggregation of Aβ peptides.
October 26, 2015 – 4:30 p.m.
Exploratory Hall, Room 3301
Refreshments will be served at 4:15 PM.
Find the schedule at http://www.cmasc.gmu.edu/seminars.htm