Biology Seminar: Inflamation, skin cancer and the paradoxical effect of the tumor progression locus 2 gene

When:
November 15, 2016 @ 3:00 pm – 4:15 pm
2016-11-15T15:00:00-05:00
2016-11-15T16:15:00-05:00
Where:
Innovation Hall, Room 131
Cost:
Free
Contact:
Department of Biology, Professor Claudette Davis

Speaker: Katie DeCicco-Skinner, PhD, Department of Biology, American University

Title: “Inflammation, skin cancer and the paradoxical effect of the tumor progression locus 2 gene”

Abstract: Cutaneous squamous cell carcinoma (cSCC), a form of non-melanoma skin cancer, is the second most common form of cancer in the United States, with over one million cases diagnosed annually. Tpl2, a gene in the mitogen-activated protein kinase (MAPK) family, can function as a tumor suppressor gene in skin cancer. Mice with a Tpl2 deletion have both an increased incidence of skin carcinogenesis and increased propensity for tumor metastasis. This study investigates whether stromal-epithelial interactions and alterations in c-MET signaling are necessary to drive skin cancer development and progression in Tpl2-/- mice, thus contributing to our understanding of the mechanisms by which Tpl2 acts as a tumor suppressor gene in skin cancer.